Preprint Article Version 1 This version is not peer-reviewed

Solid Dispersion of Resveratrol Supported on Magnesium Dihydroxide ([email protected]) Microparticles  Improves Oral Bioavailability

Version 1 : Received: 24 October 2018 / Approved: 25 October 2018 / Online: 25 October 2018 (03:53:04 CEST)

A peer-reviewed article of this Preprint also exists.

Spogli, R.; Bastianini, M.; Ragonese, F.; Iannitti, R.G.; Monarca, L.; Bastioli, F.; Nakashidze, I.; Brecchia, G.; Menchetti, L.; Codini, M.; Arcuri, C.; Mancinelli, L.; Fioretti, B. Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability. Nutrients 2018, 10, 1925. Spogli, R.; Bastianini, M.; Ragonese, F.; Iannitti, R.G.; Monarca, L.; Bastioli, F.; Nakashidze, I.; Brecchia, G.; Menchetti, L.; Codini, M.; Arcuri, C.; Mancinelli, L.; Fioretti, B. Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability. Nutrients 2018, 10, 1925.

Journal reference: Nutrients 2018, 10, 1925
DOI: 10.3390/nu10121925

Abstract

Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on magnesium dihydroxide ([email protected]) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy and granulometric analysis display three types of microparticles with similar size: type 1 that emitted preferably fluorescence at 463 nm (λecc 358 nm), type 2 that emitted preferably fluorescence at 605 nm (λecc 550 nm) andtype 3 that are non-fluorescent. Micronized pure resveratrol display only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from [email protected] in comparison to resveratrol alone displayed better solubility. According to the biopharmaceutical classification, an increase of 3 fold of resveratrol bioavailabilitywas observed after oral administration of 50 mg/Kg of resveratrol of [email protected] in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of [email protected]

Subject Areas

resveratrol; magnesium dihydroxide; solubility; bioavailability; dissolution rate; microparticles

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