Preprint Article Version 1 This version is not peer-reviewed

Synthesis, Reactivity Studies and Cytotoxicity of Two Iodidoplatinum(II) Complexes. Does Photoactivation Work?

Version 1 : Received: 19 October 2018 / Approved: 19 October 2018 / Online: 19 October 2018 (14:15:28 CEST)

A peer-reviewed article of this Preprint also exists.

Cubo, L.; Parro, T.; Carnero, A.; Salassa, L.; Matesanz, A.I.; Quiroga, A.G. Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work? Inorganics 2018, 6, 127. Cubo, L.; Parro, T.; Carnero, A.; Salassa, L.; Matesanz, A.I.; Quiroga, A.G. Synthesis, Reactivity Studies, and Cytotoxicity of Two trans-Iodidoplatinum(II) Complexes. Does Photoactivation Work? Inorganics 2018, 6, 127.

Journal reference: Inorganics 2018, 6, 127
DOI: 10.3390/inorganics6040127

Abstract

Trans platinum complexes have been the landmark in unconventional drugs prompting the development of innovative structures that might exhibit chemical and biological profiles different to cisplatin. Iodido complexes made a new turning point in the platinum drug design field since their cytotoxicity was reevaluated and reported. In this new study, we have synthesized and evaluated diodido complexes bearing aliphatic amines and pyridines in trans configuration. X-ray diffraction support the structural characterization. Their cytotoxicity has been evaluated in tumor cell lines such as SAOS-2, A375, T-47D and HCT116. Moreover, we report their solution behavior and reactivity with biological models. UVA irradiation induces an increase in their reactivity towards model nucleobase 5´-GMP in early stages, and promotes the release of the pyridine ligand (spectator ligand) at longer reaction times. Density Functional calculations have been performed and the results are compared with our previous studies with other iodido derivatives.

Subject Areas

platinum iodido complexes; cytotoxicity; photoactivation

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