Preprint Article Version 1 This version is not peer-reviewed

Assessing the Relation between Plasma PCB concentrations and Elevated Autistic Behaviours Using Bayesian Predictive Odds Ratios

Version 1 : Received: 12 October 2018 / Approved: 15 October 2018 / Online: 15 October 2018 (06:23:08 CEST)

A peer-reviewed article of this Preprint also exists.

Bernardo, B.A.; Lanphear, B.P.; Venners, S.A.; Arbuckle, T.E.; Braun, J.M.; Muckle, G.; Fraser, W.D.; McCandless, L.C. Assessing the Relation between Plasma PCB Concentrations and Elevated Autistic Behaviours using Bayesian Predictive Odds Ratios. Int. J. Environ. Res. Public Health 2019, 16, 457. Bernardo, B.A.; Lanphear, B.P.; Venners, S.A.; Arbuckle, T.E.; Braun, J.M.; Muckle, G.; Fraser, W.D.; McCandless, L.C. Assessing the Relation between Plasma PCB Concentrations and Elevated Autistic Behaviours using Bayesian Predictive Odds Ratios. Int. J. Environ. Res. Public Health 2019, 16, 457.

Journal reference: Int. J. Environ. Res. Public Health 2019, 16, 457
DOI: 10.3390/ijerph16030457

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and repetitive or stereotypic behaviours. In utero exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs), may play a role in the etiology of ASD. We examined the relation between plasma PCB concentrations measured during pregnancy and autistic behaviours in a subset of children aged 3–4 years old in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a pregnancy and birth cohort of 546 mother-infant pairs from Canada (enrolled: 2008-2011). We quantified the concentrations of 6 PCB congeners that were detected in >40% of plasma samples collected during the 1st trimester. At age 3–4 years, caregivers completed the Social Responsiveness Scale-2 (SRS), a valid and reliable measure of children’s reciprocal social and repetitive behaviors and restricted interests. We examined SRS scores as both a continuous and binary outcome, and we calculated Bayesian predictive odds ratios for more autistic behaviours based on a latent variable model for SRS scores >60. We found no association between plasma PCB concentrations and autistic behavior, However, we found small and imprecise increases in the mean SRS score and odds of more autistic behaviour for the highest quartile of plasma PCB concentrations compared with the lowest quartile; for instance, an average increase of 1.1 [95%PCI: −0.5, 2.6] in the mean SRS (exposure contrast 4th versus 1st quartile) for PCB138 translated to an odds ratio of 1.6 [95%PCI: 1.0, 2.5].  Our findings illustrate the importance of measuring associations between PCBs and autistic behaviour on both continuous and binary scales.

Subject Areas

Autism; polychlorinated biphenyls; environmental chemicals; children; neurodevelopment

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.