Preprint Article Version 1 This version is not peer-reviewed

Serum Amyloid A Was Correlated with Osteonecrosis of the Femoral Head by Affecting Bone Metabolism

Version 1 : Received: 9 October 2018 / Approved: 10 October 2018 / Online: 10 October 2018 (07:42:31 CEST)

How to cite: Peng, X.; Wang, Q.; Gao, Y.; Li, G.; Feng, Y.; Zhang, C. Serum Amyloid A Was Correlated with Osteonecrosis of the Femoral Head by Affecting Bone Metabolism. Preprints 2018, 2018100207 (doi: 10.20944/preprints201810.0207.v1). Peng, X.; Wang, Q.; Gao, Y.; Li, G.; Feng, Y.; Zhang, C. Serum Amyloid A Was Correlated with Osteonecrosis of the Femoral Head by Affecting Bone Metabolism. Preprints 2018, 2018100207 (doi: 10.20944/preprints201810.0207.v1).

Abstract

SAA is an acute phase protein that elevates under inflammatory circumstance. The serum level of SAA was associated with the progression of inflammation in numerous diseases. However, little attention was paid to the correlation between SAA and ONFH. In this study, SAA was found risen in the femoral head of osteonecrosis patients through proteomics analysis and further confirmed by ELISA. Furthermore, SAA was proven affecting bone metabolism in rBMSCs. It facilitated the proliferation of rBMSCs whereas it suppressed the osteogenic differentiation of rBMSCs and accelerated the adipogenic differentiation of rBMSCs. Thus, we deem that serum amyloid A, which is a vital acute phase protein in inflammation, affected bone metabolis and plays an imperative role in the pathophysiological process of ONFH.

Subject Areas

SAA; ONFH; proteomics; Wnt/β-catenin; PPARγ

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