Preprint Article Version 1 This version is not peer-reviewed

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Version 1 : Received: 6 October 2018 / Approved: 8 October 2018 / Online: 8 October 2018 (08:04:32 CEST)
Version 2 : Received: 26 October 2018 / Approved: 29 October 2018 / Online: 29 October 2018 (10:33:59 CET)

A peer-reviewed article of this Preprint also exists.

Ederer, K.A.; Jin, K.; Bouslog, S.; Wang, L.; Gorman, G.S.; Rowe, G.C.; Abadir, P.; Raftery, D.; Moellering, D.; Promislow, D.; Jumbo-Lucioni, P.; De Luca, M. Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster. Int. J. Mol. Sci. 2018, 19, 3351. Ederer, K.A.; Jin, K.; Bouslog, S.; Wang, L.; Gorman, G.S.; Rowe, G.C.; Abadir, P.; Raftery, D.; Moellering, D.; Promislow, D.; Jumbo-Lucioni, P.; De Luca, M. Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster. Int. J. Mol. Sci. 2018, 19, 3351.

Journal reference: Int. J. Mol. Sci. 2018, 19, 3351
DOI: 10.3390/ijms19113351

Abstract

The angiotensin-converting enzyme (ACE) is a peptidase that is involved in the synthesis of Angiotensin II, the bioactive component of the renin-angiotensin system. A growing body of literature argues for a beneficial impact of ACE inhibitors (ACEi) on age-associated metabolic disorders, mediated by cellular changes in reactive oxygen species (ROS) that improve mitochondrial function. Yet, our understanding of the relationship between ACEi therapy and metabolic parameters is limited. Here, we used three genetically diverse strains of Drosophila melanogaster to show that Lisinopril treatment reduces thoracic ROS levels and mitochondrial respiration in young flies, and increases mitochondrial content in middle-aged flies. Using untargeted metabolomics analysis, we also showed that Lisinopril perturbs the thoracic metabolic network structure by affecting metabolic pathways involved in glycogen degradation, glycolysis, and mevalonate metabolism. The Lisinopril-induced effects on mitochondrial and metabolic parameters, however, are genotype-specific and likely reflect the drug’s impact on nutrient-dependent fitness traits. Accordingly, we found that Lisinopril negatively affects survival under nutrient starvation, an effect that can be rescued by genotype and age in a manner that partially mirrors the drug-induced changes in mitochondrial respiration. In conclusion, our results provide novel and important insights into the role of ACEi in cellular metabolism.

Subject Areas

aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

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