Review
Version 1
This version is not peer-reviewed
Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Version 1
: Received: 1 October 2018 / Approved: 2 October 2018 / Online: 2 October 2018 (15:36:06 CEST)
How to cite: Quinn, J.; Axtell, R. Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Preprints 2018, 2018100031 (doi: 10.20944/preprints201810.0031.v1). Quinn, J.; Axtell, R. Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Preprints 2018, 2018100031 (doi: 10.20944/preprints201810.0031.v1).
Abstract
Multiple sclerosis is an autoimmune disorder where both T cells and B cells are implicated in pathology. However, it remains unclear how these two distinct populations cooperate to drive disease. There is ample evidence from studies in both MS patients and mouse models that Th17, B cells, and follicular T helper (TFH) cells contribute to disease. This review article describes the literature that identifies mechanisms by which Th17, TFH, and B cells cooperatively drive disease activity in MS and EAE. The curation of this literature has identified that CNS-infiltrating TFH cells act with TH17 cell to contribute to an inflammatory B cell response in neuroinflammation. This demonstrates that TFH cells and their products are promising targets for therapies in MS.
Subject Areas
TFH, B-cells, Multiple Sclerosis, EAE, TH17
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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