: Received: 6 September 2018 / Approved: 10 September 2018 / Online: 10 September 2018 (05:10:49 CEST)
: Received: 10 October 2018 / Approved: 10 October 2018 / Online: 10 October 2018 (08:45:49 CEST)
Luan, E.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors2018, 18, 3519.
Luan, E.; Shoman, H.; Ratner, D.M.; Cheung, K.C.; Chrostowski, L. Silicon Photonic Biosensors Using Label-Free Detection. Sensors 2018, 18, 3519.
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level CMOS-chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.
silicon photonics; evanescent optical field sensor; label-free SOI biosensor; Mach-Zehnder interferometer; ring resonator; photonic crystal; Bragg grating; sub-wavelength grating; lab-on-a-chip; microfluidics
ENGINEERING, Biomedical & Chemical Engineering
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