Preprint Review Version 1 This version is not peer-reviewed

Drosophila Models of Sporadic Parkinson’s Disease

Version 1 : Received: 6 September 2018 / Approved: 7 September 2018 / Online: 7 September 2018 (12:40:50 CEST)

A peer-reviewed article of this Preprint also exists.

Nagoshi, E. Drosophila Models of Sporadic Parkinson’s Disease. Int. J. Mol. Sci. 2018, 19, 3343. Nagoshi, E. Drosophila Models of Sporadic Parkinson’s Disease. Int. J. Mol. Sci. 2018, 19, 3343.

Journal reference: Int. J. Mol. Sci. 2018, 19, 3343
DOI: 10.3390/ijms19113343

Abstract

Parkinson’s disease (PD) is the most common cause of movement disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. It is increasingly recognized as a complex group of disorders presenting widely heterogenous symptoms and pathology. Except for the rare monogenic forms, the majority of the PD cases result from an interaction between multiple genetic and environmental risk factors. The search for these risk factors and the development of preclinical animal models are in progress hand in hand, providing mechanistic insights into the pathogenesis of PD. This review summarizes the studies that capitalize on modeling sporadic (i.e. non-familial) PD using Drosophila melanogaster and discuss their methodology, new findings and future perspective.

Subject Areas

Sporadic Parkinson’s disease. Drosophila, genetic risk factor, environmental risk factor,Serendipity, dopamine, neurodegeneration, animal model

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