Sá, O.M.D.S.; Lopes, N.N.F.; Alves, M.T.S.; Caran, E.M.M. Effects of Glycine in Collagen Expression and Factors Growth, Platelet (PDGF) and Epidermal (EGF) in Oral Mucositis Induced Hamster. Preprints2018, 2018090024. https://doi.org/10.20944/preprints201809.0024.v1
APA Style
Sá, O.M.D.S., Lopes, N.N.F., Alves, M.T.S., & Caran, E.M.M. (2018). Effects of Glycine in Collagen Expression and Factors Growth, Platelet (PDGF) and Epidermal (EGF) in Oral Mucositis Induced <em>Hamster</em>. Preprints. https://doi.org/10.20944/preprints201809.0024.v1
Chicago/Turabian Style
Sá, O.M.D.S., Maria Teresa Seixas Alves and Eliana Maria Monteiro Caran. 2018 "Effects of Glycine in Collagen Expression and Factors Growth, Platelet (PDGF) and Epidermal (EGF) in Oral Mucositis Induced <em>Hamster</em>" Preprints. https://doi.org/10.20944/preprints201809.0024.v1
Abstract
Oral mucositis is most frequently a toxic effect of chemotherapeutic and/or radiotherapeutic treatment, resulting from complex multifaceted biological events involving DNA damage. The clinical manifestations have a negative impact on the life quality of cancer patients. Preventive measures and curative treatment of mucositis are still not well established. The glycine has anti-inflammatory, immunomodulatory and cytoprotective actions, being a potential therapeutic in mucositis. The objective was to evaluate the effects of glycine on the expression of collagen and growth factors, platelet and epidermal in oral mucositis. The mucositis of which was induced by the protocol of Sonis. 40 hamsters were used, divided into two groups: Group I- control; Group II- supplemented with 5% intraperitoneal glycine, 2,0 mg/g diluted in hepes. Histopathological sections were used to perform the immune-histochemical method, the evaluation collagen expression and the growth factors: EGF and PDGF. It was observed that the group supplemented with glycine higher amounts of collagen expression and predominance type of collagen I. The glycine group presented lower immunoexpression of the growth factors, EGF and PDGF. The group supplemented with glycine showed a marked healing process of the oral mucosite, demonstrated by the predominance of collagen type I and reduction of growth factors, EGF and PDGF.
Keywords
oral mucositis; glycine; intercellular signaling peptides and proteins
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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