Preprint Review Version 1 This version is not peer-reviewed

Effects of Leucine Metabolite (Β-Hydroxy-Β-Methylbutyrate) Supplementation and Resistance Training on Cardiovascular Risk Factors, Oxidative Stress, and Inflammatory Markers: a Review on Recent Literature

Version 1 : Received: 29 August 2018 / Approved: 29 August 2018 / Online: 29 August 2018 (14:12:18 CEST)

A peer-reviewed article of this Preprint also exists.

Arazi, H.; Taati, B.; Suzuki, K. A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors. Antioxidants 2018, 7, 148. Arazi, H.; Taati, B.; Suzuki, K. A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors. Antioxidants 2018, 7, 148.

Journal reference: Antioxidants 2018, 7, 148
DOI: 10.3390/antiox7100148

Abstract

β-hydroxy β-methylbutyrate (HMB) is a bioactive metabolite formed from breakdown of the branched-chain amino acid leucine. Given the popularity of HMB supplements among different athletes, specifically, those who engage in regular resistance training, this review was performed to summarize current literature on some aspects of HMB supplementation that have received less attention. Because of the small number of published studies, it has not been possible to conclude the exact effects of HMB on cardiovascular parameters, oxidative stress and inflammatory markers. Thus, the interpretation of outcomes should be taken cautiously. However, the data presented here suggest that acute HMB supplementation may attenuate pro-inflammatory response following an intense resistance exercise in athletes. Also, the available findings collectively indicate that chronic HMB consumption in conjunction with resistance training has no more adaptive advantages associated with decreasing cardiovascular risk factors and oxidative stress markers. Taken together, there is clearly a need for further well-designed, longer duration studies to support these findings and determine whether HMB supplementation affects the adaptations induced by resistance training associated with body’s inflammatory condition, antioxidative defense system, and cardiovascular risk factors in humans.

Subject Areas

HMB; Branched-chain amino acid; Strength training; Sports nutrition; Inflammation.

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