Preprint Article Version 1 This version is not peer-reviewed

Cudratricusxanthone L Suppresses Lipopolysaccharide-induced Activation of BV2 and Primary Rat Microglial Cells by Inhibiting JNK, p38 MAPK, and NF-κB Signaling

Version 1 : Received: 9 August 2018 / Approved: 9 August 2018 / Online: 9 August 2018 (20:43:24 CEST)

How to cite: Kim, D.; Quang, T.H.; Oh, H.; Kim, Y. Cudratricusxanthone L Suppresses Lipopolysaccharide-induced Activation of BV2 and Primary Rat Microglial Cells by Inhibiting JNK, p38 MAPK, and NF-κB Signaling. Preprints 2018, 2018080197 (doi: 10.20944/preprints201808.0197.v1). Kim, D.; Quang, T.H.; Oh, H.; Kim, Y. Cudratricusxanthone L Suppresses Lipopolysaccharide-induced Activation of BV2 and Primary Rat Microglial Cells by Inhibiting JNK, p38 MAPK, and NF-κB Signaling. Preprints 2018, 2018080197 (doi: 10.20944/preprints201808.0197.v1).

Abstract

Neuroinflammatory responses are implicated in the pathogenesis of neurodegenerative diseases. In neurodegenerative diseases, neuroinflammatory reactions to neuronal injury are modulated by microglial cells, which are vital innate immune cells in the central nervous system. Activated microglial cells release proinflammatory cytokines, mediators, and neurotoxic factors that induce fatal neuronal injury. The present study investigated the anti-neuroinflammatory effects of cudratricusxanthone L (1), which was isolated from Cudrania tricuspidata. This compound reduced the levels of lipopolysaccharide-stimulated inflammatory mediators and cytokines, including nitric oxide, prostaglandin E2, interleukin (IL)-1β, tumor necrosis factor-α, IL-6, and IL-12. These effects suggested that cudratricusxanthone L (1) suppressed the nuclear factor-kappa B (NF-κB) signaling pathway. Specifically, cudratricusxanthone L (1) also attenuated the phosphorylation of Jun kinase and inhibited p38 mitogen-activated protein kinase (MAPK) signaling in BV2 and rat primary microglial cells. These results indicated that cudratricusxanthone L (1) effectively repressed neuroinflammatory processes in BV2 and rat primary microglial cells by inhibiting NF-κB and the MAPK signaling pathway.

Subject Areas

Cudratricusxanthone L; Cudrania tricuspidata; Neuroinflammation; Nuclear factor-kappa B (NF-κB); Mitogen-activated protein kinase (MAPK)

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.