Preprint Article Version 1 This version is not peer-reviewed

The Effects of Intravenous Lipid Emulsion Treatment in the Preventi̇on of Depressive Effects of Propofol on Cardiovascular and Respiratory System: An Experimental Animal Study

Version 1 : Received: 7 August 2018 / Approved: 7 August 2018 / Online: 7 August 2018 (07:54:12 CEST)
Version 2 : Received: 22 October 2018 / Approved: 23 October 2018 / Online: 23 October 2018 (09:34:43 CEST)

How to cite: Doğanay, F.; Ak, R.; Alışkan, H.; Abut, S.; Sümer, E.; Onur, Ö. The Effects of Intravenous Lipid Emulsion Treatment in the Preventi̇on of Depressive Effects of Propofol on Cardiovascular and Respiratory System: An Experimental Animal Study. Preprints 2018, 2018080136 (doi: 10.20944/preprints201808.0136.v1). Doğanay, F.; Ak, R.; Alışkan, H.; Abut, S.; Sümer, E.; Onur, Ö. The Effects of Intravenous Lipid Emulsion Treatment in the Preventi̇on of Depressive Effects of Propofol on Cardiovascular and Respiratory System: An Experimental Animal Study. Preprints 2018, 2018080136 (doi: 10.20944/preprints201808.0136.v1).

Abstract

Propofol is the general anesthetic used for the anesthesia induction and its continuation. Propofol is generally safe and it doesn't have an antidote. Propofol has severe side effects such as cardiovascular depression and hypotension. The aim of this study was observed the effects of intravenous lipid emulsion (ILE) treatment in the preventi̇on of depressive effects of propofol on cardiovascular and respiratory system. Twenty-eight Sprague-Dawley adult rats randomly divided into 4 groups. The saline administered group was defined as the control group. The second group administered propofol, the third group administered ILE, and the fourth administered propofol with ILE therapy. Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Median arterial blood pressure (MAP), Respiratory rate (RR), Heart rate (HR) and mortality were recorded during 60 minutes of follow-up. In the propofol group, SBP, DBP, MAP, RR and HR scores were decline steadily, after 60 minutes all rats in this group died. In the ILE group with propofol, after a while, decreased SBP, DBP, MAP, RR and HR scores was increased, and these values were observed close to the control group. The mortality ratio of the propofol group was detected as 100%, and survival ratio was found 100% in ILE + propofol group. The side effects such as hypotension, bradycardia and respiratory depression which can be seen after propofol application in rats could be recovered with ILE treatment and mortality due to these side effects were prevented.

Subject Areas

acute toxicity; intravenous lipid emulsion; propofol; rat model

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