Version 1
: Received: 5 August 2018 / Approved: 6 August 2018 / Online: 6 August 2018 (10:13:51 CEST)
Version 2
: Received: 15 September 2018 / Approved: 17 September 2018 / Online: 17 September 2018 (08:45:16 CEST)
How to cite:
Salybekov, A.A.; Salybekova, A.K.; Pola, R.; Asahara, T. Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints2018, 2018080110. https://doi.org/10.20944/preprints201808.0110.v1
Salybekov, A.A.; Salybekova, A.K.; Pola, R.; Asahara, T. Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints 2018, 2018080110. https://doi.org/10.20944/preprints201808.0110.v1
Salybekov, A.A.; Salybekova, A.K.; Pola, R.; Asahara, T. Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints2018, 2018080110. https://doi.org/10.20944/preprints201808.0110.v1
APA Style
Salybekov, A.A., Salybekova, A.K., Pola, R., & Asahara, T. (2018). Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints. https://doi.org/10.20944/preprints201808.0110.v1
Chicago/Turabian Style
Salybekov, A.A., Roberto Pola and Takayuki Asahara. 2018 "Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine" Preprints. https://doi.org/10.20944/preprints201808.0110.v1
Abstract
The Hedgehog (Hh) signaling pathway plays an essential role in embryonic and postnatal vasculature development and homeostasis of organs. Under physiological condition, Hh family’s member Sonic Hedgehog (SHh) regulates endothelial cell growth, promotes cell migration, and induces the construction of blood vessels. In this review, we highlight recent topics in EPC biology, regarding current advance in SHh canonical and non-canonical signaling pathway in EPCs and EC biology in terms of homeostasis, extracellular SHh signal transmission by parental cell-derived extracellular vesicle (exosomes containing single-strand non-codding miRNA), and SHh signal impairment in cardiovascular diseases. Also, we discuss SHh signaling pathway activation of EPCs as a promising therapeutic tool against cardiovascular disease patients.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
