Preprint Review Version 1 This version is not peer-reviewed

Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine

Version 1 : Received: 5 August 2018 / Approved: 6 August 2018 / Online: 6 August 2018 (10:13:51 CEST)
Version 2 : Received: 15 September 2018 / Approved: 17 September 2018 / Online: 17 September 2018 (08:45:16 CEST)

How to cite: Salybekov, A.A.; Salybekova, A.K.; Pola, R.; Asahara, T. Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints 2018, 2018080110 (doi: 10.20944/preprints201808.0110.v1). Salybekov, A.A.; Salybekova, A.K.; Pola, R.; Asahara, T. Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. Preprints 2018, 2018080110 (doi: 10.20944/preprints201808.0110.v1).

Abstract

The Hedgehog (Hh) signaling pathway plays an essential role in embryonic and postnatal vasculature development and homeostasis of organs. Under physiological condition, Hh family’s member Sonic Hedgehog (SHh) regulates endothelial cell growth, promotes cell migration, and induces the construction of blood vessels. In this review, we highlight recent topics in EPC biology, regarding current advance in SHh canonical and non-canonical signaling pathway in EPCs and EC biology in terms of homeostasis, extracellular SHh signal transmission by parental cell-derived extracellular vesicle (exosomes containing single-strand non-codding miRNA), and SHh signal impairment in cardiovascular diseases. Also, we discuss SHh signaling pathway activation of EPCs as a promising therapeutic tool against cardiovascular disease patients.

Subject Areas

sonic hedgehog; endothelial cells; endothelial progenitor cells; canonical signals; non-canonical signals; extracellular vesicles

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.