Submitted:
02 August 2018
Posted:
02 August 2018
You are already at the latest version
Abstract
The search for improved therapeutic approaches to breast cancer are still on going. Breast tumor kinase (BRK, also known as PTK6) is one of the targets, it is highly expressed in breast carcinomas while displaying low or no expression in the normal mammary gland, which hints at the oncogenic role of this enzyme in breast cancer. In these twenty years, an increasing number of studies have focused on understanding the cellular roles of BRK in breast cancers. This review outlines the advances made towards understanding the cellular and physiological role of BRK, the molecular and chemical inhibitors and its therapeutic significance in breast cancer.
Keywords:
breast tumor kinase (BRK)
; protein tyrosine kinase 6 (PTK6)
; breast cancer
; pathways
; therapeutics
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