Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mountains and Chasms - Surveying the Oncogenomic Publication Landscape

Version 1 : Received: 30 July 2018 / Approved: 31 July 2018 / Online: 31 July 2018 (10:21:40 CEST)

How to cite: Cordo, P. C.; Baudis, M. Mountains and Chasms - Surveying the Oncogenomic Publication Landscape. Preprints 2018, 2018070618. Cordo, P. C.; Baudis, M. Mountains and Chasms - Surveying the Oncogenomic Publication Landscape. Preprints 2018, 2018070618.


Cancers arise from the accumulation of somatic genome mutations, with varying contributions of intrinsic (i.e. genetic predisposition) and extrinsic (i.e. environmental) factors. For the understanding of malignant clones, precise information about their genomic composition has to be correlated with morphological, clinical and individual features, in the context of the available medical knowledge. Rapid improvements in molecular profiling techniques, the accumulation of large amount of data in genomic alterations in human malignancies and the expansion of bioinformatic tools and methodologies have facilitated the understanding of the molecular changes during oncogenesis, and their correlation with clinico-pathological phenotypes. Far beyond a limited set of "driver" genes, oncogenomic profiling has identified a large variety of somatic mutations; and whole genome sequencing studies of healthy individuals have improved the knowledge of heritable genome variation. Nevertheless, main challenges arise from the skewed representation of individuals from varying population backgrounds in biomedical studies, and also through the limited extend in which some cancer entities are represented in the scientific literature. Content analyses of oncogenomic publications could provide guidance for the planning and support of future studies aiming at filling prominent knowledge gaps.

Supplementary and Associated Material Progenetix cancer profiling repository


Cancer genomics; CNA; CGH; bioinformatics


Medicine and Pharmacology, Oncology and Oncogenics

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0

Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.