The Emperor Has no Clothes? Searching for Dysregulation in Sepsis

Joe Alcock

doi:10.20944/preprints201807.0486.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 July 2018 / Approved: 25 July 2018 / Online: 25 July 2018 (13:19:58 CEST)

For decades, sepsis research has been motivated by the idea of a dangerous overreaction of the immune system in sepsis. But is it true that the response to sepsis is dysregulated? This review surveys the history of sepsis trials and found that evidence for dysregulation does not exist in many of the physiologic mechanisms of sepsis. It is time to consider the alternative hypothesis, that sepsis traits are often functional, and do more harm than good. This review discusses the implications of this perspective for the future of sepsis research

sepsis; dysregulation; adaptation; evolution; natural selection; medical reversal

Medicine and Pharmacology, Pathology and Pathobiology

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The Emperor Has no Clothes? Searching for Dysregulation in Sepsis

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