Preprint Review Version 1 This version is not peer-reviewed

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans

Version 1 : Received: 13 July 2018 / Approved: 16 July 2018 / Online: 16 July 2018 (08:27:03 CEST)

A peer-reviewed article of this Preprint also exists.

Sarasija, S.; Norman, K.R. Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans. Antioxidants 2018, 7, 111. Sarasija, S.; Norman, K.R. Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans. Antioxidants 2018, 7, 111.

Journal reference: Antioxidants 2018, 7, 111
DOI: 10.3390/antiox7090111

Abstract

Neurodegenerative diseases like Alzheimer’s disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin occur in most familial Alzheimer’s disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using Caenorhabditis elegans to explore the effects of calcium dysregulation due to presenilin mutations on mitochondrial function, oxidative stress and neurodegeneration is explored.

Subject Areas

mitochondria; invertebrate; reactive oxygen species; oxidative phosphorylation

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