PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis.
Version 1
: Received: 13 July 2018 / Approved: 13 July 2018 / Online: 13 July 2018 (17:36:38 CEST)
How to cite:
Kempinska-Podhorodecka, A.; Blatkiewicz, M.; Wunsch, E.; Krupa, L.; Gutkowski, K.; Milkiewicz, P.; Milkiewicz, M. Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis.. Preprints2018, 2018070247. https://doi.org/10.20944/preprints201807.0247.v1
Kempinska-Podhorodecka, A.; Blatkiewicz, M.; Wunsch, E.; Krupa, L.; Gutkowski, K.; Milkiewicz, P.; Milkiewicz, M. Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis.. Preprints 2018, 2018070247. https://doi.org/10.20944/preprints201807.0247.v1
Kempinska-Podhorodecka, A.; Blatkiewicz, M.; Wunsch, E.; Krupa, L.; Gutkowski, K.; Milkiewicz, P.; Milkiewicz, M. Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis.. Preprints2018, 2018070247. https://doi.org/10.20944/preprints201807.0247.v1
APA Style
Kempinska-Podhorodecka, A., Blatkiewicz, M., Wunsch, E., Krupa, L., Gutkowski, K., Milkiewicz, P., & Milkiewicz, M. (2018). Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis.. Preprints. https://doi.org/10.20944/preprints201807.0247.v1
Chicago/Turabian Style
Kempinska-Podhorodecka, A., Piotr Milkiewicz and Malgorzata Milkiewicz. 2018 "Oncomir Microrna-346 is Upregulated in Ascending but Not Sigmoid Colon in Patients with Primary Sclerosing Cholangitis with Concurrent Ulcerative Colitis." Preprints. https://doi.org/10.20944/preprints201807.0247.v1
Abstract
Primary sclerosing cholangitis (PSC) is a cholestatic liver disorder frequently associated with ulcerative colitis (UC). Patients with PSC and UC have higher risk of colorectal neoplasia than patients with UC without PSC. Oncogenic properties of micro RNA 346 (miR-346) have been recently reported. In this study we investigated expressions of miR-346 and its two target genes i.e. the receptor of vitamin D (VDR) and the tumor necrosis factor α (TNF-α), which are known to modulate carcinogenesis. Biopsies from ascending and sigmoid colon were obtained from patients with PSC with and without UC, patients with UC and healthy controls. MiR-346 expression was increased in ascending but not sigmoid colon of patients with PSC and UC when compared to other analyzed groups (p<0.001 for all). In patients with UC an exceptionally low colonic expression of miRNA-346 was accompanied by the increase in VDR expression, and the extensive upregulation of TNF-α gene which protein product is known to be cytotoxic to tumor cells at high concentration. In summary, a substantial upregulation of miRNA-346 in ascending colon of patients with PSC and UC may be responsible for the inhibition of VDR and TNF-α signaling -pathway which may result in an inadequate suppression of neoplasia.
Keywords
vitamin D receptor, cytokines, miR-346, primary sclerosing cholangitis, colorectal cancer
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.