Version 1
: Received: 12 July 2018 / Approved: 13 July 2018 / Online: 13 July 2018 (04:41:38 CEST)
How to cite:
Masola, V.; Bellin, G.; Gambaro, G.; Onisto, M. Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular Signaling. Preprints2018, 2018070225. https://doi.org/10.20944/preprints201807.0225.v1
Masola, V.; Bellin, G.; Gambaro, G.; Onisto, M. Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular Signaling. Preprints 2018, 2018070225. https://doi.org/10.20944/preprints201807.0225.v1
Masola, V.; Bellin, G.; Gambaro, G.; Onisto, M. Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular Signaling. Preprints2018, 2018070225. https://doi.org/10.20944/preprints201807.0225.v1
APA Style
Masola, V., Bellin, G., Gambaro, G., & Onisto, M. (2018). Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular Signaling. Preprints. https://doi.org/10.20944/preprints201807.0225.v1
Chicago/Turabian Style
Masola, V., Giovanni Gambaro and Maurizio Onisto. 2018 "Heparanase: A Multitasking Protein Involved in Extarcellular Matrix (ECM) Remodeling and Cellular Signaling" Preprints. https://doi.org/10.20944/preprints201807.0225.v1
Abstract
Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions. Through its enzymatic activity, HPSE catalyzes the cutting of the side chains of heparan sulfate (HS) proteoglycans, thus contributing to the remodeling of the extracellular matrix and of the basal membranes. Furthermore, thanks to this activity, HPSE also promotes the release and diffusion of various HS-linked molecules as growth factors, cytokines and enzymes. In addition to being an enzyme HPSE has been shown to possess the ability to trigger different signaling pathways by interacting with transmembrane proteins. In normal tissue and in physiological conditions, HPSE exhibits only low levels of expression restricted only to keratinocytes, trophoblast, platelets and mast cells and leukocytes. On the contrary, in pathological conditions, such as in tumor progression and metastasis, inflammation and fibrosis, it is overexpressed. With this brief review, we intend to provide an update on current knowledge about the different role of HPSE protein exerted by its enzymatic and not-enzymatic activity.
Keywords
heparanase; extracellular matrix (ECM)
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
