Preprint Short Note Version 1 This version is not peer-reviewed

Bio-Catalytic Synthesis of Quercetin-3-Oleate

Version 1 : Received: 27 June 2018 / Approved: 27 June 2018 / Online: 27 June 2018 (16:01:26 CEST)

A peer-reviewed article of this Preprint also exists.

Carullo, G.; Aiello, F. Quercetin-3-oleate. Molbank 2018, 2018, M1006. Carullo, G.; Aiello, F. Quercetin-3-oleate. Molbank 2018, 2018, M1006.

Journal reference: Molbank 2018, 2018, M1006
DOI: 10.3390/M1006

Abstract

Polyphenols are well-known health promoting agents, but they have some limitations due to their spontaneous oxidation. This evidence has limited their use as drugs in the last years. In this field, several chemical modifications have been proposed to overcome these restrictions; among these, the esterification seems to be the preferred. Ester derivatives could be able to reduce the bioavailability problems connected to polyphenols. On the other hand, the presence of the esterase enzymes in the body guarantees the ester hydrolysis, which in turn frees the two molecules that make it up. Lipase-catalyzed esterifications afforded several derivatives of flavonoids glycosides, in green conditions. In this short note, pancreatic porcine lipase was firstly used as a cheap bio-catalyst, to synthesize oleoyl derivatives of quercetin in aglycone form. Results demonstrated how the enzyme acyl regioselective in position C-3, with high yields and easy purification processes

Subject Areas

Pancreatic Porcine Lipase, Regio-selectivity; Quercetin derivatives, Oleic acid, ecofriendly reaction, scalable process.

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.