Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes

Olga Dolgova; Oscar Lao

doi:10.20944/preprints201806.0287.v1

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preprints.org > biology and life sciences > anatomy and physiology > doi: 10.20944/preprints201806.0287.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes

Olga Dolgova

^* and

Oscar Lao

Version 1 : Received: 15 June 2018 / Approved: 19 June 2018 / Online: 19 June 2018 (10:12:15 CEST)

A peer-reviewed article of this Preprint also exists.

Dolgova, O.; Lao, O. Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes. Genes 2018, 9, 358. Dolgova, O.; Lao, O. Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes. Genes 2018, 9, 358.

Abstract

The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly abundant and available even from extinct hominins, new insights of the evolutionary history of our species are discovered. It is currently known that AMH introgressed with archaic hominins once they left the African continent. Current out of African human genomes carry fragments of archaic origin. This review focuses on the fitness consequences of archaic interbreeding in current human populations. We discuss new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.

Keywords

archaic introgression, fitness, natural selection, Neanderthal, Denisova, anatomically modern humans

Subject

Biology and Life Sciences, Anatomy and Physiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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