Preprint Review Version 1 This version is not peer-reviewed

Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes

Version 1 : Received: 15 June 2018 / Approved: 19 June 2018 / Online: 19 June 2018 (10:12:15 CEST)

A peer-reviewed article of this Preprint also exists.

Dolgova, O.; Lao, O. Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes. Genes 2018, 9, 358. Dolgova, O.; Lao, O. Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes. Genes 2018, 9, 358.

Journal reference: Genes 2018, 9, 358
DOI: 10.3390/genes9070358

Abstract

The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly abundant and available even from extinct hominins, new insights of the evolutionary history of our species are discovered. It is currently known that AMH introgressed with archaic hominins once they left the African continent. Current out of African human genomes carry fragments of archaic origin. This review focuses on the fitness consequences of archaic interbreeding in current human populations. We discuss new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.

Subject Areas

archaic introgression, fitness, natural selection, Neanderthal, Denisova, anatomically modern humans

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