Review
Version 2
Preserved in Portico This version is not peer-reviewed
Building Principles for Constructing a Mammalian Blastocyst Embryo
Version 1
: Received: 13 June 2018 / Approved: 13 June 2018 / Online: 13 June 2018 (10:34:59 CEST)
Version 2 : Received: 25 July 2018 / Approved: 25 July 2018 / Online: 25 July 2018 (05:43:59 CEST)
Version 2 : Received: 25 July 2018 / Approved: 25 July 2018 / Online: 25 July 2018 (05:43:59 CEST)
A peer-reviewed article of this Preprint also exists.
Pfeffer, P.L. Building Principles for Constructing a Mammalian Blastocyst Embryo. Biology 2018, 7, 41. Pfeffer, P.L. Building Principles for Constructing a Mammalian Blastocyst Embryo. Biology 2018, 7, 41.
Abstract
The self-organisation of a fertilised egg to form a blastocyst structure, which consists of three distinct cell lineages (trophoblast, epiblast and hypoblast) arranged around an off-centre cavity, is unique to mammals. While the starting point (the zygote) and endpoint (the blastocyst) are similar in all mammals, the intervening events have diverged. This review examines and compares the descriptive and functional data surrounding embryonic gene activation, symmetry-breaking, first and second lineage establishment, and fate commitment in a wide range of mammalian orders. The exquisite detail known from mouse embryogenesis, embryonic stem cell studies and the wealth of recent single cell transcriptomic experiments are used to highlight the building principles underlying early mammalian embryonic development.
Keywords
lineage determination; patterning; blastomere polarization; compaction; cleavage stages; morula; gene regulatory networks
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
