Version 1
: Received: 6 June 2018 / Approved: 7 June 2018 / Online: 7 June 2018 (12:22:21 CEST)
How to cite:
Sudirman, S.; Hsu, Y.; He, J.; Kong, Z. Red Seaweed Eucheuma cottonii Ethanol Extract Regulates Inflammatory Mediators Production and Prevents Colonic Injury on Acute Colitis Disease in Mice. Preprints2018, 2018060120. https://doi.org/10.20944/preprints201806.0120.v1
Sudirman, S.; Hsu, Y.; He, J.; Kong, Z. Red Seaweed Eucheuma cottonii Ethanol Extract Regulates Inflammatory Mediators Production and Prevents Colonic Injury on Acute Colitis Disease in Mice. Preprints 2018, 2018060120. https://doi.org/10.20944/preprints201806.0120.v1
Sudirman, S.; Hsu, Y.; He, J.; Kong, Z. Red Seaweed Eucheuma cottonii Ethanol Extract Regulates Inflammatory Mediators Production and Prevents Colonic Injury on Acute Colitis Disease in Mice. Preprints2018, 2018060120. https://doi.org/10.20944/preprints201806.0120.v1
APA Style
Sudirman, S., Hsu, Y., He, J., & Kong, Z. (2018). Red Seaweed <em>Eucheuma cottonii</em> Ethanol Extract Regulates Inflammatory Mediators Production and Prevents Colonic Injury on Acute Colitis Disease in Mice. Preprints. https://doi.org/10.20944/preprints201806.0120.v1
Chicago/Turabian Style
Sudirman, S., Jia-Ling He and Zwe-Ling Kong. 2018 "Red Seaweed <em>Eucheuma cottonii</em> Ethanol Extract Regulates Inflammatory Mediators Production and Prevents Colonic Injury on Acute Colitis Disease in Mice" Preprints. https://doi.org/10.20944/preprints201806.0120.v1
Abstract
This study aims to determine the protective effects of red seaweed Eucheuma cottonii (EC) ethanol extract on acute colitis disease in mice. Male BALB/c mice used for acute colitis disease model by induced 2.5% (w/v) of dextran sulfate sodium (DSS) for 7 days for all groups, except control group. The DSS-induced mice then treated by three different doses of EC extracts (0.35, 0.70, 1.75 g/kg body weight), curcumin (as a positive control, 0.10 g/kg), and a group was orally only by water. In 8th day, the mice sacrificed and collected the blood, then measured the body weight, colon weight, and colon length. Disease activity index (DAI), pro-inflammatory such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, as well as IL-10 as anti-inflammatory were measured. The results showed that after treatment for 7 days, EC extract protected the weight loss and decreased the colon weight per length ratio. In addition, EC extract also decreased the pro-inflammatory cytokines expression in serum and increased the IL-10. Moreover, EC extract protected the colonic tissue damage. According to this results, the EC ethanol extract might be can used for the treatment of colitis disease.
Keywords
colitis disease; Eucheuma cottonii; inflammatory cytokines; red seaweed
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
