Preprint Article Version 1 This version is not peer-reviewed

Short Version of 'The Brain, Explained': A Response Process Theory of Brain Function

Version 1 : Received: 5 June 2018 / Approved: 7 June 2018 / Online: 7 June 2018 (06:02:29 CEST)

How to cite: Rappoport, A. Short Version of 'The Brain, Explained': A Response Process Theory of Brain Function. Preprints 2018, 2018060092 (doi: 10.20944/preprints201806.0092.v1). Rappoport, A. Short Version of 'The Brain, Explained': A Response Process Theory of Brain Function. Preprints 2018, 2018060092 (doi: 10.20944/preprints201806.0092.v1).

Abstract

Understanding brain function is one of the most important open problems in science today. At present, there is no concrete theory for how the brain works. Here, a theory is presented that provides a detailed mechanistic biological account of the brain’s capacities. Brain function is managed by a response (R) process that is structurally similar to the immune response, and shows anatomical and molecular specificity. Different R process stages utilize different cortical layers, hippocampus fields, basal ganglia paths, GABAergic interneurons, cerebellum paths, and molecular agents such as dopamine, serotonin and opioids. We show how the R process supports hierarchical action sequences, language and thought. The theory is supported by a large body of experimental evidence in many modalities, and accounts for virtually all of the major facts known about the brain at the system level.

Subject Areas

Neuroscience; basal ganglia; cortical layers; cerebellum; habenula; inhibition; predictions; dopamine; serotonin; acetylcholine; opioids; mirror neurons; place cells; language; imagery; working memory

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