Version 1
: Received: 31 May 2018 / Approved: 1 June 2018 / Online: 1 June 2018 (05:45:19 CEST)
How to cite:
Grauso, F.; Autiero, R.; Lannino, G.R.; Zizolfi, B.; Perone, C.; Messalli, E.M. The Role of the Endocannabinoid System in the Gynaecological Malignancy. Preprints2018, 2018060001. https://doi.org/10.20944/preprints201806.0001.v1
Grauso, F.; Autiero, R.; Lannino, G.R.; Zizolfi, B.; Perone, C.; Messalli, E.M. The Role of the Endocannabinoid System in the Gynaecological Malignancy. Preprints 2018, 2018060001. https://doi.org/10.20944/preprints201806.0001.v1
Grauso, F.; Autiero, R.; Lannino, G.R.; Zizolfi, B.; Perone, C.; Messalli, E.M. The Role of the Endocannabinoid System in the Gynaecological Malignancy. Preprints2018, 2018060001. https://doi.org/10.20944/preprints201806.0001.v1
APA Style
Grauso, F., Autiero, R., Lannino, G.R., Zizolfi, B., Perone, C., & Messalli, E.M. (2018). The Role of the Endocannabinoid System in the Gynaecological Malignancy. Preprints. https://doi.org/10.20944/preprints201806.0001.v1
Chicago/Turabian Style
Grauso, F., Ciro Perone and Enrico M. Messalli. 2018 "The Role of the Endocannabinoid System in the Gynaecological Malignancy" Preprints. https://doi.org/10.20944/preprints201806.0001.v1
Abstract
Background: The endocannabinoid system (ECS) is a very heterogeneous array consisting of many proteins like ligands, enzymes and receptors synthetized in various tissues and immunity cells. The main endogenous ligands are unsaturated fatty acid derivatives like anandamide(AEA), 2-arachidonoylglycerol(2-AG), but many others are under study. Endocannabinoids are involved in both physiological and pathological conditions. ECS plays an important role in the regulation of main processes which lead to cancer and also in sex steroid hormone-related cancers. Methods: With focus on gynaecological cancers, main papers and review articles, up to April 2018, on the role of the ECS, were acquired by PubMed searches using the search terms: ‘cancer’, ‘cannabinoid’, ‘endocannabinoid’, ‘gynaecology’ and ‘malignancy’. Results: The review of recent literature data showed the involvement of the endocannabinoid system in numerous physiological and pathological conditions of the female genital tract up to the development of gynaecological malignancy as cervical, endometrial and ovarian cancer. Conclusions: The endocannabinoid system has an important role in antitumor actions involving different signalling receptor and receptor-independent pathways. It represents an exciting challenge to researchers for its potential use in diagnosis and treatment of all gynaecological malignancies
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
