Preprint Article Version 1 This version is not peer-reviewed

The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination

Version 1 : Received: 30 May 2018 / Approved: 31 May 2018 / Online: 31 May 2018 (10:51:16 CEST)
Version 2 : Received: 5 July 2018 / Approved: 6 July 2018 / Online: 6 July 2018 (07:53:32 CEST)

A peer-reviewed article of this Preprint also exists.

Plant, E.P.; Eick-Cost, A.A.; Ezzeldin, H.; Sanchez, J.L.; Ye, Z.; Cooper, M.J. The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination. Vaccines 2018, 6, 39. Plant, E.P.; Eick-Cost, A.A.; Ezzeldin, H.; Sanchez, J.L.; Ye, Z.; Cooper, M.J. The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination. Vaccines 2018, 6, 39.

Journal reference: Vaccines 2018, 6, 39
DOI: 10.3390/vaccines6030039

Abstract

The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts. With the development of new universal vaccines there is need for better understanding of how vaccine responses are affected by early exposures to influenza viruses. In this analysis of hemagglutination inhibition (HI) antibody responses in two cohorts of military personnel we noticed differences related to birth year. These data suggest that HI antibody production, in response to influenza vaccination, is affected by influenza activity in the years following birth. The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth.

Subject Areas

influenza; serum; IgG; humoral antibody; original antigenic sin; hemagglutinin

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