Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals. International Journal of Molecular Sciences 2018, 19, 2121, doi:10.3390/ijms19072121.
Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals. International Journal of Molecular Sciences 2018, 19, 2121, doi:10.3390/ijms19072121.
Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals. International Journal of Molecular Sciences 2018, 19, 2121, doi:10.3390/ijms19072121.
Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and Its Binding Partners in Mammals. International Journal of Molecular Sciences 2018, 19, 2121, doi:10.3390/ijms19072121.
Abstract
Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, proline-rich regions and a C-terminal PDZ-binding motif. We and other groups have identified various binding partners for Rhotekin and proposed their possible physiological roles. However, functions of Rhotekin per se are largely unknown and information about its physiological roles are fragmentary. In this review, we summarize known features of Rhotekin in neuronal tissues and cancer cells. We also describe characteristics of binding partners for Rhotekin and predicted roles of their interaction.
Keywords
Rho; Rhotekin; PDZ domain; SH3 domain
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
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