Preprint Review Version 1 This version is not peer-reviewed

Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals

Version 1 : Received: 25 May 2018 / Approved: 28 May 2018 / Online: 28 May 2018 (10:20:19 CEST)

How to cite: Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals. Preprints 2018, 2018050395 (doi: 10.20944/preprints201805.0395.v1). Ito, H.; Morishita, R.; Nagata, K. Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals. Preprints 2018, 2018050395 (doi: 10.20944/preprints201805.0395.v1).

Abstract

Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, proline-rich regions and a C-terminal PDZ-binding motif. We and other groups have identified various binding partners for Rhotekin and proposed their possible physiological roles. However, functions of Rhotekin per se are largely unknown and information about its physiological roles are fragmentary. In this review, we summarize known features of Rhotekin in neuronal tissues and cancer cells. We also describe characteristics of binding partners for Rhotekin and predicted roles of their interaction.

Subject Areas

Rho; Rhotekin; PDZ domain; SH3 domain

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