Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals

Hidenori Ito; Rika Morishita; Koh-ichi Nagata

doi:10.20944/preprints201805.0395.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 25 May 2018 / Approved: 28 May 2018 / Online: 28 May 2018 (10:20:19 CEST)

Rhotekin is an effector protein for small GTPase Rho. This protein consists of a Rho binding domain (RBD), a pleckstrin homology (PH) domain, proline-rich regions and a C-terminal PDZ-binding motif. We and other groups have identified various binding partners for Rhotekin and proposed their possible physiological roles. However, functions of Rhotekin per se are largely unknown and information about its physiological roles are fragmentary. In this review, we summarize known features of Rhotekin in neuronal tissues and cancer cells. We also describe characteristics of binding partners for Rhotekin and predicted roles of their interaction.

Rho; Rhotekin; PDZ domain; SH3 domain

Biology and Life Sciences, Cell and Developmental Biology

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Functions of Rhotekin, an Effector of Rho GTPase, and its Binding Partners in Mammals

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