Preprint Review Version 1 This version is not peer-reviewed

Role of GDNF in Spinal Cord Injury Repair

Version 1 : Received: 17 May 2018 / Approved: 17 May 2018 / Online: 17 May 2018 (12:54:50 CEST)

How to cite: Walker, M.J.; Xu, X. Role of GDNF in Spinal Cord Injury Repair. Preprints 2018, 2018050247 (doi: 10.20944/preprints201805.0247.v1). Walker, M.J.; Xu, X. Role of GDNF in Spinal Cord Injury Repair. Preprints 2018, 2018050247 (doi: 10.20944/preprints201805.0247.v1).

Abstract

Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, also in combination with other factors and cell transplantations, for repairing the injured spinal cord. As recent decades of studies strongly suggest combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.

Subject Areas

spinal cord injury; glial cell line-derived neurotrophic factor (GDNF), GFRα-1; cRET; Schwann cells; Astrogliosis; neuroprotection; axonal regeneration; combinational therapies; neurotrauma

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