Submitted:
17 May 2018
Posted:
17 May 2018
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Abstract
Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, also in combination with other factors and cell transplantations, for repairing the injured spinal cord. As recent decades of studies strongly suggest combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.
Keywords:
spinal cord injury
; glial cell line-derived neurotrophic factor (GDNF)
; GFRα-1
; cRET
; Schwann cells
; Astrogliosis
; neuroprotection
; axonal regeneration
; combinational therapies
; neurotrauma
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
