Preprint Article Version 1 This version is not peer-reviewed

Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus

Version 1 : Received: 15 May 2018 / Approved: 16 May 2018 / Online: 16 May 2018 (06:28:36 CEST)

How to cite: Yamada, T.; Matsuda, M.; Seki, M.; Hirose, M.; Kikuchi, T. Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus. Preprints 2018, 2018050222 (doi: 10.20944/preprints201805.0222.v1). Yamada, T.; Matsuda, M.; Seki, M.; Hirose, M.; Kikuchi, T. Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus. Preprints 2018, 2018050222 (doi: 10.20944/preprints201805.0222.v1).

Abstract

Sterepinic acids A–C (13), new carboxylic acids with two primary alcohols, have been isolated from a fungal strain of Stereum sp. OUPS-124D-1 attached to the marine alga Undaria pinnatifida. Dihydro-1,5-secovibralactone (4), a new vibralactone derivative, was isolated from the same fungal metabolites together with known vibralactone A (5), and 1,5-secovibralactone (6). The planar structures of these compounds have been elucidated by spectroscopic analyses using IR, HRFABMS, and NMR spectra. To determine the absolute configuration of the compounds, we used the phenylglycine methyl ester (PGME) method. These compounds exhibited less activity in the cytotoxicity assay against cancer cell lines.

Subject Areas

terepinic acids; Stereum sp.; marine microorganism; Undaria pinnatifida; vibralactones; phenylglycine methyl ester method

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