Preprint Article Version 1 This version is not peer-reviewed

Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents

Version 1 : Received: 21 April 2018 / Approved: 24 April 2018 / Online: 24 April 2018 (08:46:31 CEST)

How to cite: Ahammad, I. Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints 2018, 2018040311 (doi: 10.20944/preprints201804.0311.v1). Ahammad, I. Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints 2018, 2018040311 (doi: 10.20944/preprints201804.0311.v1).

Abstract

Cocaine addiction is a global health problem that causes substantial damage to the health of addicted individuals around the world. Dopamine synthesizing neurons in the brain play a vital role in the addiction to cocaine. But the underlying molecular mechanisms that help cocaine exert its addictive effect have not been very well understood. Bioinformatics can be a useful tool in the attempt to broaden our understanding in this area. In the present study, Gene Set Enrichment Analysis (GSEA) was carried out on the upregulated genes from a dataset of Dopamine synthesizing neurons of post-mortem human brain of cocaine addicts. As a result of this analysis, 3 miRNAs have been identified as having significant influence on transcription of the upregulated genes. These 3 miRNAs hold therapeutic potential for the treatment of cocaine addiction.

Subject Areas

GSEA; cocaine; addiction; enrichment analysis; bioinformatics; in silico research

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