Version 1
: Received: 21 April 2018 / Approved: 24 April 2018 / Online: 24 April 2018 (08:46:31 CEST)
How to cite:
Ahammad, I. Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints2018, 2018040311. https://doi.org/10.20944/preprints201804.0311.v1
Ahammad, I. Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints 2018, 2018040311. https://doi.org/10.20944/preprints201804.0311.v1
Ahammad, I. Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints2018, 2018040311. https://doi.org/10.20944/preprints201804.0311.v1
APA Style
Ahammad, I. (2018). Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents. Preprints. https://doi.org/10.20944/preprints201804.0311.v1
Chicago/Turabian Style
Ahammad, I. 2018 "Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents" Preprints. https://doi.org/10.20944/preprints201804.0311.v1
Abstract
Cocaine addiction is a global health problem that causes substantial damage to the health of addicted individuals around the world. Dopamine synthesizing neurons in the brain play a vital role in the addiction to cocaine. But the underlying molecular mechanisms that help cocaine exert its addictive effect have not been very well understood. Bioinformatics can be a useful tool in the attempt to broaden our understanding in this area. In the present study, Gene Set Enrichment Analysis (GSEA) was carried out on the upregulated genes from a dataset of Dopamine synthesizing neurons of post-mortem human brain of cocaine addicts. As a result of this analysis, 3 miRNAs have been identified as having significant influence on transcription of the upregulated genes. These 3 miRNAs hold therapeutic potential for the treatment of cocaine addiction.
Keywords
GSEA; cocaine; addiction; enrichment analysis; bioinformatics; in silico research
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
