Preprint Review Version 1 This version is not peer-reviewed

Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides

Version 1 : Received: 19 April 2018 / Approved: 19 April 2018 / Online: 19 April 2018 (14:28:02 CEST)

A peer-reviewed article of this Preprint also exists.

Simón-Gracia, L.; Hunt, H.; Teesalu, T. Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides. Molecules 2018, 23, 1190. Simón-Gracia, L.; Hunt, H.; Teesalu, T. Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides. Molecules 2018, 23, 1190.

Journal reference: Molecules 2018, 23, 1190
DOI: 10.3390/molecules23051190

Abstract

During last decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies – a grim condition known as peritoneal carcinomatosis (PC). Intraperitoneal administration can be used to achieve elevated local concentration and extended half-life of the drugs in the peritoneal cavity to improve their anticancer efficacy. However, IP-administered chemotherapeutics have a short residence time in the IP space, and are not tumor selective. An increasing body of work suggests that functionalization of drugs and nanoparticles with targeting peptides increases their peritoneal retention and provides a robust and specific tumor binding and penetration that translates into improved therapeutic response. Here we review a progress in affinity targeting of intraperitoneal anticancer compounds, imaging agents and nanoparticles with tumor homing peptides. We review classes of tumor homing peptides relevant for PC targeting, payloads for peptide-guided precision delivery, applications for targeted compounds and the effects of nanoformulation of drugs and imaging agents on affinity-based tumor delivery.

Subject Areas

peritoneal carcinomatosis, tumor homing peptide, nanoparticle, intraperitoneal chemotherapy, image guided surgery, affinity targeting, integrins, cd206, nucleolin

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