Preprint Review Version 1 This version is not peer-reviewed

Network Medicine and Alzheimer’s Disease Therapy

Version 1 : Received: 17 April 2018 / Approved: 18 April 2018 / Online: 18 April 2018 (07:41:00 CEST)

A peer-reviewed article of this Preprint also exists.

Jarrell, J.T.; Gao, L.; Cohen, D.S.; Huang, X. Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine. Molecules 2018, 23, 1143. Jarrell, J.T.; Gao, L.; Cohen, D.S.; Huang, X. Network Medicine for Alzheimer’s Disease and Traditional Chinese Medicine. Molecules 2018, 23, 1143.

Journal reference: Molecules 2018, 23, 1143
DOI: 10.3390/molecules23051143

Abstract

Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future.

Subject Areas

Alzheimer’s Disease; network medicine; inflammation; network and system pharmacology; traditional Chinese medicine

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