Version 1
: Received: 9 March 2018 / Approved: 12 March 2018 / Online: 12 March 2018 (05:11:45 CET)
How to cite:
Perekhoda, L.O.; Drapak, I.V.; Suleiman, M.M.; Rakhimova, M.V.; Таran, S.G.; Yaremenko, V.D.; Gerashchenko, I.V. A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole. Preprints2018, 2018030078. https://doi.org/10.20944/preprints201803.0078.v1
Perekhoda, L.O.; Drapak, I.V.; Suleiman, M.M.; Rakhimova, M.V.; Таran, S.G.; Yaremenko, V.D.; Gerashchenko, I.V. A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole. Preprints 2018, 2018030078. https://doi.org/10.20944/preprints201803.0078.v1
Perekhoda, L.O.; Drapak, I.V.; Suleiman, M.M.; Rakhimova, M.V.; Таran, S.G.; Yaremenko, V.D.; Gerashchenko, I.V. A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole. Preprints2018, 2018030078. https://doi.org/10.20944/preprints201803.0078.v1
APA Style
Perekhoda, L.O., Drapak, I.V., Suleiman, M.M., Rakhimova, M.V., Таran, S.G., Yaremenko, V.D., & Gerashchenko, I.V. (2018). A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole. Preprints. https://doi.org/10.20944/preprints201803.0078.v1
Chicago/Turabian Style
Perekhoda, L.O., Vitaliy D. Yaremenko and Inna V. Gerashchenko. 2018 "A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole" Preprints. https://doi.org/10.20944/preprints201803.0078.v1
Abstract
The purpose of our work was the search for safe and effective biologically active substances of cardiotropic action among 1,3- thiazole derivatives. New derivatives of 1-[(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-yl]ethan-1-one and ethyl-(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-carboxylate were synthesized by the Hantzsch reaction. The structure of the compounds obtained was confirmed by 1H NMR spectroscopy and by the elemental analysis. The pharmacological screening showed that the obtained substances possess cardiotropic activity. The cardiotropic properties of the new 1,3-thiazole derivatives were studied on the isolated rings of the thoracic aorta of laboratory rats. A prospective substance 1-[(2Z)-2-[(4-methoxyphenyl)imin]-4-methyl-3-(4-methylpiperazin-1-yl) -2,3-dihydro-1,3-thiazol-5-yl]ethan-1-one hydrochloride, which exhibits cardiotropic activity exceeding the activity of L-carnitine and meldonia has been revealed during pharmacological researches of the substances obtained.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
