Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Estimating the Burden of Serious Fungal Infections in Uruguay

Version 1 : Received: 6 February 2018 / Approved: 6 February 2018 / Online: 6 February 2018 (06:52:38 CET)

A peer-reviewed article of this Preprint also exists.

Macedo-Viñas, M.; Denning, D.W. Estimating the Burden of Serious Fungal Infections in Uruguay. J. Fungi 2018, 4, 37. Macedo-Viñas, M.; Denning, D.W. Estimating the Burden of Serious Fungal Infections in Uruguay. J. Fungi 2018, 4, 37.


We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure: total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk: HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006 (19.7% of older than 40); asthma in adults 223,431 (prevalence 9%); cystic fibrosis in adults 48; tuberculosis 613 (incidence 26.2%), lung cancer 1,400 (ASR incidence 27.4). Annual incidence estimations per 100,000: 22.4 invasive aspergillosis, 16.4 candidaemia, 3.7 Candida peritonitis, 1.62 Pneumocystis jirovecii pneumonia, 0.75 cryptococcosis, severe asthma with fungal sensitisation 217, allergic bronchopulmonary aspergillosis 165, recurrent Candida vaginitis 6,323, oral candidiasis 74.5 and oesophageal candidiasis 25.7. Although some under and overestimations could have been made, we expect that at least 127,525 people suffer from serious fungal infections each year. Sporothrichosis, histoplasmosis, paracoccidioidomycosis and dermatophytosis are known to be frequent but no data are available to make accurate estimations. Given the magnitude of the burden of fungal infections in Uruguay, efforts should be made to improve surveillance, strengthen laboratory diagnosis and warrant access to first line antifungals.


epidemiology of fungal infections; infection burden; Uruguay


Biology and Life Sciences, Immunology and Microbiology

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