Preprint Article Version 1 This version is not peer-reviewed

Outflow Enhancement by Three Different ab Interno Trabeculectomy Procedures in a Porcine Anterior Segment Model

Version 1 : Received: 1 February 2018 / Approved: 5 February 2018 / Online: 5 February 2018 (03:50:14 CET)
Version 2 : Received: 23 March 2018 / Approved: 27 March 2018 / Online: 27 March 2018 (05:13:49 CEST)

How to cite: Dang, Y.; Wang, C.; Shah, P.; Waxman, S.; Loewen, R.T.; Hong, Y.; Esfandiari, H..; Loewen, N.A. Outflow Enhancement by Three Different ab Interno Trabeculectomy Procedures in a Porcine Anterior Segment Model. Preprints 2018, 2018020028 (doi: 10.20944/preprints201802.0028.v1). Dang, Y.; Wang, C.; Shah, P.; Waxman, S.; Loewen, R.T.; Hong, Y.; Esfandiari, H..; Loewen, N.A. Outflow Enhancement by Three Different ab Interno Trabeculectomy Procedures in a Porcine Anterior Segment Model. Preprints 2018, 2018020028 (doi: 10.20944/preprints201802.0028.v1).

Abstract

Objective: To evaluate three different microincisional ab interno trabeculectomy procedures in a porcine eye perfusion model. Methods: In perfused porcine anterior segments, 90 degrees of trabecular meshwork (TM) were ablated using the Trabectome (T; n = 8), Goniotome (G; n = 8), or Kahook device (K; n = 8). After 24 hours, additional 90 degrees of TM were removed. Intraocular pressure (IOP) and outflow facility were measured at 5 µL/min and 10 µL/min perfusion to simulate an elevated IOP. Structure and function were assessed with canalograms and histology. Results: At 5 µL/min infusion rate, T resulted in a greater IOP reduction than G or K from baseline (76.12% decrease versus 48.19% and 47.96%, P = 0.013). IOP reduction between G and K was similar (P = 0.420). Removing another 90 degrees of TM caused an additional IOP reduction only in T and G but not in K. Similarly, T resulted in the largest increase in outflow facility at 5 µL/min compared with G and K (first ablation: 3.41 times increase versus 1.95 and 1.87; second ablation: 4.60 versus 2.50 and 1.74) with similar results at 10 µL/min (first ablation: 3.28 versus 2.29 and 1.90 (P = 0.001); second ablation: 4.10 versus 3.01 and 2.01 (P = 0.001)). Canalograms indicated circumferential flow beyond the ablation endpoints. Conclusions: T, G and K significantly increased the outflow facility. In this model, T had a larger effect than G and K.

Subject Areas

glaucoma; ab interno trabeculectomy; goniotome; trabectome; Kahook Dual Blade; MIGS; minimally invasive surgery

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