Version 1
: Received: 14 December 2017 / Approved: 15 December 2017 / Online: 15 December 2017 (12:01:47 CET)
Version 2
: Received: 29 December 2017 / Approved: 2 January 2018 / Online: 2 January 2018 (05:21:45 CET)
How to cite:
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v1
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints 2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v1
Haslam, C.; Damiati, S.; Whitley, T.; Davey, P.; Ifeachor, E.; Awan, S.A. Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints2017, 2017120106. https://doi.org/10.20944/preprints201712.0106.v1
APA Style
Haslam, C., Damiati, S., Whitley, T., Davey, P., Ifeachor, E., & Awan, S.A. (2017). Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Preprints. https://doi.org/10.20944/preprints201712.0106.v1
Chicago/Turabian Style
Haslam, C., Emmanuel Ifeachor and Shakil A. Awan. 2017 "Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker" Preprints. https://doi.org/10.20944/preprints201712.0106.v1
Abstract
We report on the development of chemical vapour deposition (CVD) based graphene field effect transistor (GFET) immunosensors for the sensitive detection of Human Chorionic Gonadotropin (hCG), a glycoprotein risk biomarker of certain cancers. The GFET sensors were fabricated on Si/SiO2 substrate using photolithography with evaporated chromium and sputtered gold contacts. GFET channels were functionalized with a linker molecule to immobile anti-hCG antibody on the surface of graphene. Binding reaction of the antibody with varying concentration levels of hCG antigen demonstrated the limit of detection of the GFET sensors was ~0.1 pg/mL using four-probe electrical measurements. We also show annealing can significantly improve the carrier transport properties of GFETs and shift the Dirac point (Fermi level) with reduced p-doping in back-gated measurements. The developed GFET biosensors are generic and could find applications in a broad range of medical diagnostics in addition to cancer, such as neurodegenerative (Alzheimer’s, Parkinson’s and Lewy body) and cardiovascular disorders.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
