Preprint Article Version 1 This version not peer reviewed

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Version 1 : Received: 5 December 2017 / Approved: 5 December 2017 / Online: 5 December 2017 (08:19:17 CET)
Version 2 : Received: 27 January 2018 / Approved: 30 January 2018 / Online: 30 January 2018 (08:03:04 CET)

A peer-reviewed article of this Preprint also exists.

Dhaneria, M.; Jain, S.; Singh, P.; Mathur, A.; Lundborg, C.S.; Pathak, A. Incidence and Determinants of Health Care-Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study. Diseases 2018, 6, 14. Dhaneria, M.; Jain, S.; Singh, P.; Mathur, A.; Lundborg, C.S.; Pathak, A. Incidence and Determinants of Health Care-Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study. Diseases 2018, 6, 14.

Journal reference: Diseases 2018, 6, 14
DOI: 10.3390/diseases6010014

Abstract

Very little is known about healthcare-associated infections (HAIs) in neonatal intensive care units (NICUs) in resource-limited settings including, India. The aim of this prospective study was to determine the prevalence, onset, risk factors and causative agents of laboratory confirmed blood stream (LBCI) as a HAI in a level-2 NICU at RD Gardi Medical College, Ujjain, India. The diagnosis of HAI was established using the Centre for Disease Control, USA criteria. A predesigned questionnaire containing risk factors associated with BSHAI was filled. A total of 150 neonates (43% preterm) were included in the study. The incidence of LBCI was 31%; 56% of which was late onset sepsis. The independent risk factors for LBCI were: preterm (Odds Ratio OR 3.22), duration of NICU stay more than 14 days (OR 2.38), chorioamnionitis in the mother (OR 18.48), neonate born through meconium stained amniotic fluid (OR 4.53), mal-presentation (OR 10.58), endotracheal intubation (OR 11.60), umbilical catheterization (OR 15.11), HAI due to ventilator-associated pneumonia (VAP) (OR 11.88). Initiation of minimal enteral nutrition was protective (OR 0.15). The predominant causative organisms were Gram-negative pathogens (58%). Among Klebsiella spp. and E. coli isolates, 73 and 80%, respectively were identified as extended-spectrum beta-lactamase producers. The results can be used to identify high-risk neonates for LBCI.

Subject Areas

blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.