Does Irisin Link Physical Exercise with Alzheimer&rsquo;s Disease?

Dewan Md. Sumsuzzman; Yunho Jin; Jeonghyun Choi; Sang-Rae Lee; Yonggeun Hong

doi:10.20944/preprints201712.0023.v2

How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About

Advanced Search

Submit preprint Login Register

Share this article with

Create alert

Email:

Load new image

preprints.org > life sciences > endocrinology & metabolomics > doi: 10.20944/preprints201712.0023.v2

Preprint Review Version 2 This version is not peer-reviewed

Does Irisin Link Physical Exercise with Alzheimer’s Disease?

Dewan Md. Sumsuzzman , Yunho Jin , Jeonghyun Choi , Sang-Rae Lee ^* , Yonggeun Hong ^*

Version 1 : Received: 3 December 2017 / Approved: 4 December 2017 / Online: 4 December 2017 (08:46:17 CET)
Version 2 : Received: 9 February 2018 / Approved: 11 February 2018 / Online: 11 February 2018 (04:28:07 CET)

How to cite: Sumsuzzman, D.M.; Jin, Y.; Choi, J.; Lee, S.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v2). Sumsuzzman, D.M.; Jin, Y.; Choi, J.; Lee, S.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v2).

Cite as:

Sumsuzzman, D.M.; Jin, Y.; Choi, J.; Lee, S.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v2). Sumsuzzman, D.M.; Jin, Y.; Choi, J.; Lee, S.; Hong, Y. Does Irisin Link Physical Exercise with Alzheimer’s Disease?. Preprints 2017, 2017120023 (doi: 10.20944/preprints201712.0023.v2).

Abstract

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors and modification of telomere length. Such beneficial effects may inhibit or delay the emergence of neurodegenerative diseases, including Alzheimer’s disease (AD). This review is based on the hypothesis that irisin produced by physical exercise helps control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD. Although current and ongoing studies on irisin show promising results, further research is required to clarify its potential as a meaningful therapeutic target for treating human diseases.

Subject Areas

physical exercise; irisin; neurodegeneration; aging; Alzheimer’s disease

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Get PDF Cite Share

Readers' Comments and Ratings (0)

Your full name

Your affiliation information (e.g., name of your university/institution/organization)

Not displayed online.

Your Email address (not made public)

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors I want to get recognition for my comment on Publons

[what’s this?]. Link your accounts here I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

Leave a public comment
Send a private comment to the author(s)
Rate this article