Preprint Article Version 1 This version not peer reviewed

Synthesis and Antiproliferative Activity of Diethylamine Mannich Base of Asymmetrical Mono-Carbonyl Curcumin Analogs against HeLa Cell Lines

Version 1 : Received: 14 November 2017 / Approved: 14 November 2017 / Online: 14 November 2017 (10:26:47 CET)

How to cite: Wiji Prasetyaningrum, P.; Bahtiar, A.; Hayun, H. Synthesis and Antiproliferative Activity of Diethylamine Mannich Base of Asymmetrical Mono-Carbonyl Curcumin Analogs against HeLa Cell Lines. Preprints 2017, 2017110091 (doi: 10.20944/preprints201711.0091.v1). Wiji Prasetyaningrum, P.; Bahtiar, A.; Hayun, H. Synthesis and Antiproliferative Activity of Diethylamine Mannich Base of Asymmetrical Mono-Carbonyl Curcumin Analogs against HeLa Cell Lines. Preprints 2017, 2017110091 (doi: 10.20944/preprints201711.0091.v1).

Abstract

A series of diethylamine Mannich base of asymmetrical mono-carbonyl analogs of curcumin (AMACs) were synthesized and evaluated for cytotoxic activity against Hela Cell lines. The structures of the synthesized compounds were confirmed on the basis of FTIR, 1H-NMR, 13C-NMR and mass spectral data. Preliminary cytotoxic test using BSLT showed that all the synthesized compounds exhibited more potent cytotoxic activity than that of curcumin. While results of MTT assay showed that all the synthesized compounds exhibited more potent antiproliferative activity against HeLa cell lines than that of cisplatin. Compound 2b exhibited as the most potent compound of the series. Compound 2a, 2b, 2c, and 2f had IC50 (µM) less than that of compound 1a, 1b, 1c and 1f indicating that the addition of diethylamine Mannich base improves the antiproliferative activity of the parent compound.

Subject Areas

diethylamine Mannich base; asymmetrical mono-carbonyl analogs of curcumin; AMACs; synthesis; cytotoxicity; antiproliferative activity; Hela cell lines

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