Halloysite nanotubes (HNTs) are natural occurring mineral clay nanotubes that have excellent application potential in different fields. However, HNTs are affected by size effect, surface electron effect and hydrogen bond formation on the surface which lead to weak affinity and prone to reunion at some extent. It is very significant to modify the HNTs’ surface for expand its applications. In this review, the structural characteristics, performance and the related applications of surface modification HNTs are reviewed and summarized. we focus on the surface modified methods of HNTs, the effect of surface modification on materials and its related applications in various regions. In addition, future prospects and the meaning of surface modification have been discussed in HNTs studies. This review provided a reference for the application of HNTs modifications in new fields.