Preprint Review Version 1 NOT YET PEER-REVIEWED

Nanotherapy for Early Dementia: Targeting Senile Endothelium

Version 1 : Received: 13 September 2017 / Approved: 13 September 2017 / Online: 13 September 2017 (05:44:29 CEST)

How to cite: D'Arrigo, J.S. Nanotherapy for Early Dementia: Targeting Senile Endothelium. Preprints 2017, 2017090050 (doi: 10.20944/preprints201709.0050.v1). D'Arrigo, J.S. Nanotherapy for Early Dementia: Targeting Senile Endothelium. Preprints 2017, 2017090050 (doi: 10.20944/preprints201709.0050.v1).

Abstract

Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted LCM/ND lipid nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine. This multitasking therapeutic targets cell-surface scavenger receptors (mainly SR-BI), making possible for various Alzheimer's-related cell types to be simultaneously searched out for localized drug treatment in vivo. Besides targeting cell-surface SR-BI, the proposed LCM/ND-nanoemulsion combination therapeutic(s) include a characteristic lipid-coated microbubble [LCM] subpopulation (i.e., a stable LCM suspension); such film-stabilized microbubbles are well known to substantially reduce the acoustic power levels needed for accomplishing temporary noninvasive (transcranial) ultrasound treatment, or sonoporation, if additionally desired for the Alzheimer's patient.

Subject Areas

Alzheimer's-disease; dementia; drug targeting; nanoemulsion; neuroinflammation; oxidative stress; scavenger receptors; sonoporation; transcranial ultrasound

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