Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Nanotherapy for Early Dementia: Targeting Senile Endothelium

Version 1 : Received: 13 September 2017 / Approved: 13 September 2017 / Online: 13 September 2017 (05:44:29 CEST)

How to cite: D'Arrigo, J.S. Nanotherapy for Early Dementia: Targeting Senile Endothelium. Preprints 2017, 2017090050. D'Arrigo, J.S. Nanotherapy for Early Dementia: Targeting Senile Endothelium. Preprints 2017, 2017090050.


Due to the complexity of Alzheimer's disease, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted lipid nanoemulsion) are available. Versatile small molecule drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By incorporating such drug(s) into the targeted LCM/ND lipid nanoemulsion type, one obtains a multitasking combination therapeutic for translational medicine. This multitasking therapeutic targets cell-surface scavenger receptors (mainly SR-BI), making possible for various Alzheimer's-related cell types to be simultaneously searched out for localized drug treatment in vivo. Besides targeting cell-surface SR-BI, the proposed LCM/ND-nanoemulsion combination therapeutic(s) include a characteristic lipid-coated microbubble [LCM] subpopulation (i.e., a stable LCM suspension); such film-stabilized microbubbles are well known to substantially reduce the acoustic power levels needed for accomplishing temporary noninvasive (transcranial) ultrasound treatment, or sonoporation, if additionally desired for the Alzheimer's patient.


Alzheimer's-disease; dementia; drug targeting; nanoemulsion; neuroinflammation; oxidative stress; scavenger receptors; sonoporation; transcranial ultrasound


Medicine and Pharmacology, Neuroscience and Neurology

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