Version 1
: Received: 10 September 2017 / Approved: 11 September 2017 / Online: 11 September 2017 (08:22:24 CEST)
Version 2
: Received: 6 October 2017 / Approved: 6 October 2017 / Online: 6 October 2017 (16:15:42 CEST)
How to cite:
Ma, J.; Zhou, Q.; Li, H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy. Preprints.org2017, 2017090040. https://doi.org/10.20944/preprints201709.0040.v1
Ma, J.; Zhou, Q.; Li, H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy. Preprints.org 2017, 2017090040. https://doi.org/10.20944/preprints201709.0040.v1
Cite as:
Ma, J.; Zhou, Q.; Li, H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy. Preprints.org2017, 2017090040. https://doi.org/10.20944/preprints201709.0040.v1
Ma, J.; Zhou, Q.; Li, H. Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy. Preprints.org 2017, 2017090040. https://doi.org/10.20944/preprints201709.0040.v1
Abstract
Gut microbiota play critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance, which highlighted the potential of gut microbiota-targeted therapies on these diseases. There are various ways that can manipulate gut microbiota including probiotics, prebiotics, synbiotics, antibiotics and some active components from herbal medicines. In this review, we first described the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies in NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiota-targeted therapies in the future.
Keywords
gut microbiota; obesity; insulin resistance; NAFLD; probiotic; prebiotic; symbiotic
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
