Preprint Article Version 1 This version not peer reviewed

Calcium Sparks in Cardiac Cells in Silico

Version 1 : Received: 29 June 2017 / Approved: 30 June 2017 / Online: 30 June 2017 (11:29:29 CEST)

How to cite: Ryvkin, A.; Markov, N. Calcium Sparks in Cardiac Cells in Silico. Preprints 2017, 2017060131 (doi: 10.20944/preprints201706.0131.v1). Ryvkin, A.; Markov, N. Calcium Sparks in Cardiac Cells in Silico. Preprints 2017, 2017060131 (doi: 10.20944/preprints201706.0131.v1).

Abstract

We simulate elementary calcium release events (sparks) in a single calcium release unit in ventricular myocyte. Previously developed and tested electron-conformational model of the stochastic dynamics of RyR-channels is integrated to the calcium dynamics model in the cardiac cell. This approach allows to observe RyRs opening/closing in details on the macromolecular level during the calcium dynamics course. We simulate calcium diffusion in the dyadic space and “domino-like” RyR’s activation during the so-called “calcium induced-calcium release process”. Ca2+ sparks initiation, spread and termination are investigated in the computer experiments. Sparks’ initiation and termination rate dependence on the Ca2+ diffusion velocity is observed. We show that sarcoplasmic reticulum lumen local depletion and RyR’s stochastic attrition could be the reasons of Ca2+ spark termination.

Subject Areas

calcium signaling; calcium release; sparks; ventricular cardiac myocytes; RyR-channels

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