Preprint Article Version 1 This version is not peer-reviewed

Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats

Version 1 : Received: 14 June 2017 / Approved: 16 June 2017 / Online: 16 June 2017 (04:20:07 CEST)

How to cite: Ma, C.; Ran, J.; Xu, K.; Xu, L.; Yang, Y.; Sun, M.; Liu, A.; Yan, S.; Wu, L. Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats. Preprints 2017, 2017060072 (doi: 10.20944/preprints201706.0072.v1). Ma, C.; Ran, J.; Xu, K.; Xu, L.; Yang, Y.; Sun, M.; Liu, A.; Yan, S.; Wu, L. Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats. Preprints 2017, 2017060072 (doi: 10.20944/preprints201706.0072.v1).

Abstract

As a chronic disease, osteoarthritis (OA) leads to degradation of both cartilage and subchondral bone, of which the development is related to proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of Specnvezhenide in osteoarthritis and mechanism of it was studied in vitro and in vivo. The results showed that Specnvezhenide decreases interleukin-1β-induced expression of matix-degrading enzymes and reduces the activation of NF-κB and wnt/β-catenin pathways in vitro. Furthermore, Specnvezhenide treatment prevents the degeneration of both cartilage and subchondral bone in rats OA model. As conclusion, to the best of our knowledge, we report firstly that Specnvezhenide decreases interleukin-1β-induced inflammation on rat chondrocytes by inhibiting activation of NF-κB and wnt/β-catenin pathways, and has therapeutic potential in OA treatment.

Subject Areas

Specnvezhenide; osteoarthritis; chondrocyte; NF-κB; wnt/β-catenin

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