Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats

Chiyuan Ma; Jisheng Ran; Kai Xu; Langhai Xu; Yute Yang; Miao Sun; An Liu; Shigui Yan; Lidong Wu

doi:10.20944/preprints201706.0072.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 14 June 2017 / Approved: 16 June 2017 / Online: 16 June 2017 (04:20:07 CEST)

As a chronic disease, osteoarthritis (OA) leads to degradation of both cartilage and subchondral bone, of which the development is related to proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of Specnvezhenide in osteoarthritis and mechanism of it was studied in vitro and in vivo. The results showed that Specnvezhenide decreases interleukin-1β-induced expression of matix-degrading enzymes and reduces the activation of NF-κB and wnt/β-catenin pathways in vitro. Furthermore, Specnvezhenide treatment prevents the degeneration of both cartilage and subchondral bone in rats OA model. As conclusion, to the best of our knowledge, we report firstly that Specnvezhenide decreases interleukin-1β-induced inflammation on rat chondrocytes by inhibiting activation of NF-κB and wnt/β-catenin pathways, and has therapeutic potential in OA treatment.

Specnvezhenide; osteoarthritis; chondrocyte; NF-κB; wnt/β-catenin

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Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats

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