Preprint Review Version 1 This version is not peer-reviewed

Modifications of Porphyrins and Hydroporphyrins for their Solubilization in Aqueous Media

Version 1 : Received: 6 June 2017 / Approved: 6 June 2017 / Online: 6 June 2017 (07:51:04 CEST)

A peer-reviewed article of this Preprint also exists.

Luciano, M.; Brückner, C. Modifications of Porphyrins and Hydroporphyrins for Their Solubilization in Aqueous Media. Molecules 2017, 22, 980. Luciano, M.; Brückner, C. Modifications of Porphyrins and Hydroporphyrins for Their Solubilization in Aqueous Media. Molecules 2017, 22, 980.

Journal reference: Molecules 2017, 22, 980
DOI: 10.3390/molecules22060980

Abstract

The increasing popularity of porphyrins and hydroporphyrins for application in a variety of biomedical (photodynamic therapy, fluorescence tagging and imaging, photoacoustic imaging) and technical (chemosensing, catalysis, light harvesting) applications is also associated with the growing number of methodologies that enable their solubilization in aqueous media. Natively, the vast majority of synthetic porphyrinic compounds are not water-soluble. Moreover, any water-solubility imposes several restrictions on the synthetic chemist on when to install solubilizing groups in the synthetic sequence, and how to isolate and purify these compounds. This review summarizes the chemical modifications to render synthetic porphyrins water-soluble, with a focus on the work since 2000. Where available, practical data such as solubility, indicators for the degree of aggregation, and special notes for the practicioner are listed. We hope that this review will guide synthetic chemists through the many strategies known to make porphyrins and hydroporphyrins water soluble.

Subject Areas

water-solubility; porphyrin; chlorin; bacteriochlorin; PEGylation; bioconjugation; photodynamic therapy; bioimaging

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.