Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

HepPar1-Positive Circulating Microparticles are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection

Valeria Abbate
,
Margherita Marcantoni
,
Felice Giuliante
,
Fabio M. Vecchio
,
Ilaria Gatto
,
Caterina Mele
,
Antonio Saviano
ORCID logo ,
Damiano Arciuolo
,
Eleonora Gaetani
,
Maria C. Ferrari
,
Igor Giarretta
,
Francesco Ardito
,
Laura Riccardi
,
Alberto Nicoletti
,
Francesca R. Ponziani
,
Antonio Gasbarrini
* ,
Maurizio Pompili
,
Roberto Pola
* ORCID logo
Version 1 : Received: 27 April 2017 / Approved: 3 May 2017 / Online: 3 May 2017 (09:53:22 CEST)

A peer-reviewed article of this Preprint also exists.

Abbate, V.; Marcantoni, M.; Giuliante, F.; Vecchio, F.M.; Gatto, I.; Mele, C.; Saviano, A.; Arciuolo, D.; Gaetani, E.; Ferrari, M.C.; Giarretta, I.; Ardito, F.; Riccardi, L.; Nicoletti, A.; Ponziani, F.R.; Gasbarrini, A.; Pompili, M.; Pola, R. HepPar1-Positive Circulating Microparticles Are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection. Int. J. Mol. Sci. 2017, 18, 1043. Abbate, V.; Marcantoni, M.; Giuliante, F.; Vecchio, F.M.; Gatto, I.; Mele, C.; Saviano, A.; Arciuolo, D.; Gaetani, E.; Ferrari, M.C.; Giarretta, I.; Ardito, F.; Riccardi, L.; Nicoletti, A.; Ponziani, F.R.; Gasbarrini, A.; Pompili, M.; Pola, R. HepPar1-Positive Circulating Microparticles Are Increased in Subjects with Hepatocellular Carcinoma and Predict Early Recurrence after Liver Resection. Int. J. Mol. Sci. 2017, 18, 1043.

Abstract

Circulating microparticles (MPs) are novel potential biomarkers in cancer patients. Their role in hepatocellular carcinoma (HCC) is under intensive investigation. In this study we tested the hypothesis that MPs expressing the antigen HepPar1 are increased in the blood of subjects with HCC and may serve as markers of early recurrence after liver resection (LR). We studied fifteen patients affected by HCC undergoing LR and used flow cytometry to assess the number of circulating HepPar1+ MPs. Ten subjects without HCC (five with liver cirrhosis and 5 with healthy liver) were used as controls. After LR, HCC patients were followed-up for early recurrence, which occurred in seven cases. The number of circulating HepPar1+ MPs was significantly higher in subjects affected by HCC, compared to individuals without cancer (p<0.01). We also found that, among HCC patients, the number of circulating HepPar1+ MPs, measured before LR, was significantly higher in those who displayed early recurrence compared to those without recurrence (p=0.02). Of note, other types of circulating MPs, such as those derived from endothelial cells (CD144+) or those produced by the activated endothelium (CD144+/CD62+) were not associated with HCC, neither could predict HCC recurrence. HepPar1+ MPs deserve further investigation as novel biomarkers of disease and prognosis in HCC patients.

Keywords

microparticles, biomarkers, hepatocellular carcinoma

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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