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Interleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects
Version 1
: Received: 10 January 2017 / Approved: 10 January 2017 / Online: 10 January 2017 (10:27:41 CET)
How to cite:
Kok, Y.; Ong, H.; Say, Y. Interleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects. Preprints2017, 2017010050. https://doi.org/10.20944/preprints201701.0050.v1
Kok, Y.; Ong, H.; Say, Y. Interleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects. Preprints 2017, 2017010050. https://doi.org/10.20944/preprints201701.0050.v1
Kok, Y.; Ong, H.; Say, Y. Interleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects. Preprints2017, 2017010050. https://doi.org/10.20944/preprints201701.0050.v1
APA Style
Kok, Y., Ong, H., & Say, Y. (2017). Interleukin-1 Receptor Antagonist (<em>IL1RA</em>) and Interleukin-4 (<em>IL4</em>) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects. Preprints. https://doi.org/10.20944/preprints201701.0050.v1
Chicago/Turabian Style
Kok, Y., Hing-Huat Ong and Yee-How Say. 2017 "Interleukin-1 Receptor Antagonist (<em>IL1RA</em>) and Interleukin-4 (<em>IL4</em>) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects" Preprints. https://doi.org/10.20944/preprints201701.0050.v1
Abstract
IL1RA intron 2 86-bp repeat and IL4 intron 3 70-bp repeat are VNTRs that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of IL1RA and IL4 VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of IL1RA and IL4 were significantly different among ethnicities, and the alleles were associated with total body fat (TBF) classes. Individuals with IL1RA I/II genotype or allele II had greater risk of having higher adiposity - even after controlling for ethnicity [Odds Ratio (OR) of I/II genotype = 12.21 (CI = 2.54, 58.79; p = 0.002); II allele = 5.78 (CI = 1.73, 19.29; p = 0.004)]. However, IL4 VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity [OR = 1.53 (CI = 1.04, 2.23; p = 0.03)]. TBF was also significantly higher in those with IL1RA II allele compared with I allele (31.79 ± 2.52 vs. 23.51 ± 0.40; p = 0.005). Taken together, IL1RA intron 3 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.
Keywords
Interleukin-1 receptor antagonist (IL-1Ra); Interleukin-4 (IL-4); Variable Number Tandem Repeat (VNTR); obesity; adiposity; Malaysia.
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
