Preprint
Concept Paper

Implantable Systems for Continuous Liquorpheresis and CSF Replacement

This version is not peer-reviewed.

Submitted:

30 January 2017

Posted:

30 January 2017

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Abstract
Liquorpheresis (CSF filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. CSF replacement may be an alternative approach not explored so far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous developments and provide some new technical innovations in order to design bidirectional CSF shunting systems. These systems can be complemented either with a deposit of artificial CSF or with a CSF filter, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF.
Keywords: 
csf; shunt; filtration; neurodegenerative; neuroimmunology; alzheimer; parkinson; guillain-barre; device; ventriculo-peritoneal shunt
Subject: 
Medicine and Pharmacology  -   Neuroscience and Neurology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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