Preprint Article Version 1 NOT YET PEER-REVIEWED

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Version 1 : Received: 1 November 2016 / Approved: 1 November 2016 / Online: 1 November 2016 (09:54:24 CET)

A peer-reviewed article of this Preprint also exists.

Du, Y.; Cai, Q.; Xue, J.; Zhang, Q. Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid. Crystals 2016, 6, 164. Du, Y.; Cai, Q.; Xue, J.; Zhang, Q. Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid. Crystals 2016, 6, 164.

Journal reference: Crystals 2016, 6, 164
DOI: 10.3390/cryst6120164

Abstract

Cocrystallizaiton could improve most physicochemical properties of specific active pharmaceutical ingredients, which has great potential in pharmaceutical development. In this study, the cocrystal of nitrofurantoin and 4-aminobenzoic acid was prepared with solid-state (solvent-free or green-chemistry) grinding approach, and the above cocrystal has been characterized by Raman and terahertz vibrational spectroscopic techniques. Spectral results show that the vibrational modes of the cocrystal within the whole spectral region are different from those of the corresponding parent materials. The dynamic process of such pharmaceutical cocrystal formation has also been monitored directly with Raman spectra. These results offer us unique means for characterizing the cocrystal conformation from molecule-level and also provide us rich information about the reaction dynamic of cocrystal formation within pharmaceutical fields.

Subject Areas

nitrofurantoin; active pharmaceutical ingredient; 4-aminobenzoic acid; cocrystallization; intermolecular interaction; Raman spectroscopy; terahertz spectroscopy

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