Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

Katherine M. Weh; Jennifer Clarke; Laura A. Kresty

doi:10.20944/preprints201608.0160.v2

Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 15 August 2016 / Approved: 16 August 2016 / Online: 16 August 2016 (13:03:30 CEST)
Version 2 : Received: 17 August 2016 / Approved: 18 August 2016 / Online: 18 August 2016 (07:44:23 CEST)

Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections to reduced cardiovascular disease and more recently cancer inhibition. A review of cranberry research targeting cancer revealed positive effects of cranberries or cranberry derived constituents against 17 different cancers utilizing a variety of in vitro techniques; whereas, in vivo studies supported the inhibitory action of cranberries toward cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma and lymphoma. Mechanisms of cranberry-linked cancer inhibition include cellular death induction via apoptosis, necrosis and autophagy; reduction of cellular proliferation; alterations in reactive oxygen species; and modification of cytokine and signal transduction pathways. Given the emerging positive preclinical effects of cranberries, future clinical directions targeting cancer or premalignancy will be considered

cranberry; cancer; proanthocyanidin; quercetin; ursolic acid

MEDICINE & PHARMACOLOGY, Nutrition

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Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents

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